Zhengliang Ma Selected Research

Bone Neoplasms (Bone Cancer)

11/2020	The analgesic effects of pioglitazone in the bone cancer pain rats via regulating the PPARγ/PTEN/mTOR signaling pathway in the spinal dorsal horn.
10/2020	Spinal cannabinoid receptor 2 activation reduces hypersensitivity associated with bone cancer pain and improves the integrity of the blood-spinal cord barrier.
1/2020	Endoplasmic Reticulum Stress Contributes to Nociception via Neuroinflammation in a Murine Bone Cancer Pain Model.
12/2019	Cannabinoid receptor 2‑selective agonist JWH015 attenuates bone cancer pain through the amelioration of impaired autophagy flux induced by inflammatory mediators in the spinal cord.
11/2018	[Intrathecal injection of AG-490 reduces bone-cancer-induced spinal cord astrocyte reaction and thermal hyperalgesia in a mouse model].
1/2018	Dehydrocorydaline attenuates bone cancer pain by shifting microglial M1/M2 polarization toward the M2 phenotype.
5/2017	Etanercept attenuates thermal and mechanical hyperalgesia induced by bone cancer.
1/2017	A Single Intrathecal or Intraperitoneal Injection of CB2 Receptor Agonist Attenuates Bone Cancer Pain and Induces a Time-Dependent Modification of GRK2.
2/2016	Role of nitric oxide synthase in the development of bone cancer pain and effect of L-NMMA.
1/2016	CREB-regulated transcription coactivator 1 enhances CREB-dependent gene expression in spinal cord to maintain the bone cancer pain in mice.

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Zhengliang Ma Research Topics

Disease

48	Pain (Aches) 03/2022 - 12/2009
39	Hyperalgesia 01/2022 - 12/2009
18	Bone Neoplasms (Bone Cancer) 11/2020 - 10/2010
15	Postoperative Pain 03/2022 - 12/2009
13	Neuralgia (Stump Neuralgia) 02/2019 - 10/2010
10	Cognitive Dysfunction 03/2022 - 01/2012
7	Inflammation (Inflammations) 04/2020 - 07/2012
6	Chronic Pain 03/2022 - 07/2014
5	Postoperative Cognitive Complications 03/2022 - 01/2012
5	Neoplasms (Cancer) 05/2017 - 10/2010
4	Neuroinflammatory Diseases 03/2022 - 01/2012
4	Hypersensitivity (Allergy) 10/2020 - 01/2017
4	Spinal Cord Injuries (Spinal Cord Injury) 01/2018 - 04/2014
4	Surgical Wound 03/2017 - 09/2014
3	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2022 - 01/2016
3	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 10/2021
3	Kyphosis 12/2018 - 02/2013
3	Ankylosing Spondylitis 12/2018 - 02/2013
3	Osteosarcoma (Osteogenic Sarcoma) 01/2018 - 07/2012
3	Peripheral Nerve Injuries 01/2018 - 07/2013
3	Cancer Pain 09/2014 - 07/2012
2	Acute Pain 01/2022 - 01/2020
2	Ischemia 10/2021 - 01/2012
2	Insulin Resistance 01/2021 - 01/2020
2	Hyperglycemia 01/2021 - 01/2020
2	Type 2 Diabetes Mellitus (MODY) 01/2021 - 01/2020
2	Memory Disorders (Memory Loss) 01/2020 - 01/2018
2	Hypertrophy 01/2019 - 10/2014
2	Scoliosis 11/2018 - 04/2015
2	Edema (Dropsy) 03/2015 - 04/2014

Drug/Important Bio-Agent (IBA)

14	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 11/2016 - 12/2009
12	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2012
11	Analgesics (Analgesic Drugs)IBA 03/2022 - 11/2013
11	CytokinesIBA 11/2017 - 04/2014
11	Remifentanil (Ultiva)FDA Link 03/2017 - 12/2009
10	Isoflurane FDA LinkGeneric 03/2022 - 03/2016
10	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2021 - 10/2010
8	Interleukin-6 (Interleukin 6)IBA 03/2022 - 01/2012
7	salicylhydroxamic acid (SHAM)IBA 11/2018 - 10/2010
6	Messenger RNA (mRNA)IBA 11/2018 - 01/2012
5	InterleukinsIBA 01/2020 - 04/2014
4	Antisense OligonucleotidesIBA 11/2020 - 07/2013
4	Cannabinoid Receptors (Cannabinoid Receptor)IBA 10/2020 - 04/2014
4	Phosphotransferases (Kinase)IBA 01/2020 - 07/2014
4	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 02/2019 - 09/2014
4	N-Methylaspartate (NMDA)IBA 01/2019 - 12/2009
4	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2018 - 12/2014
4	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 08/2017 - 01/2015
3	EnzymesIBA 12/2020 - 04/2014
3	Dexmedetomidine FDA Link 03/2020 - 08/2017
3	Dexamethasone (Maxidex)FDA LinkGeneric 03/2020 - 06/2011
3	Ketamine FDA LinkGeneric 01/2020 - 12/2009
3	N- (1- azabicyclo(2.2.2)oct- 3- yl)furo(2,3- c)pyridine- 5- carboxamideIBA 01/2019 - 01/2015
3	1- (5- chloro- 2,4- dimethoxyphenyl)- 3- (5- methylisoxazol- 3- yl)ureaIBA 01/2019 - 01/2015
3	Spironolactone (Aldactone)FDA LinkGeneric 01/2019 - 06/2011
3	Mifepristone (RU 486)FDA Link 01/2019 - 06/2011
3	Opioid Analgesics (Opioids)IBA 01/2017 - 12/2009
3	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA 01/2017 - 07/2013
3	RoscovitineIBA 09/2014 - 07/2012
3	NR2B NMDA receptorIBA 11/2013 - 12/2009
2	General AnestheticsIBA 03/2022 - 01/2021
2	Insulin (Novolin)FDA Link 01/2021 - 01/2020
2	Fentanyl (Sublimaze)FDA LinkGeneric 11/2020 - 03/2020
2	Pioglitazone (Actos)FDA Link 11/2020 - 04/2020
2	Matrix Metalloproteinase 9 (Gelatinase B)IBA 07/2020 - 03/2017
2	Cysteine (L-Cysteine)FDA Link 07/2020 - 03/2017
2	GTP-Binding Proteins (G-Protein)IBA 07/2020 - 01/2020
2	Estrogen ReceptorsIBA 07/2020 - 01/2020
2	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 01/2019 - 06/2017
2	GlucocorticoidsIBA 01/2019 - 01/2017
2	CorticosteroneIBA 01/2019 - 06/2017
2	MelatoninIBA 01/2018 - 03/2016
2	Interleukin-10 (Interleukin 10)IBA 01/2018 - 04/2015
2	Morphine (MS Contin)FDA LinkGeneric 11/2017 - 12/2014
2	JHW 015IBA 01/2017 - 10/2015
2	CB2 Cannabinoid ReceptorIBA 01/2017 - 04/2014
2	Minocycline (Cyclops)FDA LinkGeneric 01/2017 - 01/2016
2	bovine adrenal medulla 8-22IBA 01/2016 - 01/2015
2	Anesthetics (Anesthetic Agents)IBA 01/2016 - 01/2015
2	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 01/2016 - 06/2014
2	KN 93IBA 07/2015 - 09/2014
2	mu Opioid Receptors (mu Opioid Receptor)IBA 05/2015 - 09/2014
2	RE1-silencing transcription factorIBA 05/2015 - 09/2014
2	ImmunosorbentsIBA 03/2015 - 04/2014
2	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA 03/2015 - 04/2014
2	CurcuminIBA 03/2015 - 04/2014
2	Cyclin-Dependent Kinase 5IBA 07/2014 - 07/2012
2	Tyrosine (L-Tyrosine)FDA Link 07/2014 - 12/2009
1	danegaptideIBA 03/2022
1	Connexin 43 (Connexin43)IBA 03/2022
1	Hypnotics and Sedatives (Sedatives)IBA 03/2022

Therapy/Procedure

16	Spinal Injections 10/2020 - 01/2012
12	Therapeutics 03/2022 - 10/2010
11	Anesthesia 03/2022 - 03/2016
5	Intraperitoneal Injections 07/2020 - 10/2010
4	Analgesia 03/2022 - 11/2013
3	Osteotomy 12/2018 - 02/2013
3	General Anesthesia 01/2016 - 01/2015
1	Aftercare (After-Treatment) 03/2022
1	Thoracotomy 03/2022